Kufanana nevarongi vemaguta vanoronga kufamba kwemotokari munzvimbo dzemaguta, masero anotonga kufamba kwemamorekuru kuburikidza nemiganhu yavo yenyukireya. Vachishanda sevanorinda madiki, mapore enyukireya (NPCs) ari mumembrane yenyukireya anochengetedza kutonga kwakarurama pamusoro pekutengeserana kwemamorekuru uku. Basa guru kubva kuTexas A&M Health riri kuratidza kusarudza kwakasimba kwehurongwa uhwu, zvichigona kupa maonero matsva pazvirwere zvetsinga nekukura kwegomarara.
Kutevera Kuchinja-chinja Kwenzira dzeMamorekuru
Chikwata chevaongorori vaDr. Siegfried Musser kuTexas A&M College of Medicine chatanga kuferefeta nezvekufambiswa nekukurumidza kwemamorekuru pasina kuroverana kuburikidza nechinhu chinovhara membrane mbiri chenucleus. Bhuku ravo reNature rinotsanangura zvakawanikwa zvitsva zvakagoneka netekinoroji yeMINFLUX - nzira yepamusoro yekufungidzira inokwanisa kubata mafambiro emamorekuru e3D anoitika mumamiliseconds pachikero chakapetwa ka100,000 kupfuura upamhi hwebvudzi remunhu. Kusiyana nefungidziro dzekare nezvenzira dzakaparadzaniswa, tsvakiridzo yavo inoratidza kuti maitiro ekupinda nekuburitsa enyukireya ane nzira dzinopindirana mukati meNPC structure.
Zvinoshamisa Zvakawanikwa Zvinopikisa MaModheru Aripo
Zvakaonekwa nechikwata zvakaratidza maitiro asingatarisirwi ekufamba: mamorekuru anofamba nenzira mbiri kuburikidza nenzira dzakamanikana, achitenderera pane kutevera nzira dzakatsaurirwa. Zvinoshamisa kuti, zvidimbu izvi zvinoungana pedyo nemadziro enzira, zvichisiya nzvimbo yepakati isina chinhu, nepo kufambira mberi kwavo kuchinonoka zvikuru - kanenge ka1,000 zvishoma pane kufamba kusina kukanganiswa - nekuda kwemapuroteni anovhara anogadzira nzvimbo ine syrup.
Musser anotsanangura izvi se "nzvimbo yakaoma zvikuru yemotokari inofungidzirwa - kufamba munzira mbiri kuburikidza nepamukoto wakamanikana." Anobvuma kuti, "Zvatakawana zvinoratidza musanganiswa wemikana isingatarisirwi, zvichiratidza kuomarara kukuru kupfuura zvakataurwa nepfungwa dzedu dzepakutanga."
Kushanda Nesimba Pasinei Nezvipingamupinyi
Zvinoshamisa kuti masisitimu ekufambisa eNPC anoratidza kushanda zvakanaka pasinei nezvirambidzo izvi. Musser anofungidzira kuti, "Kuwanda kwemaNPC kunogona kudzivirira kushanda kwakawandisa, zvichideredza zvinobudirira kupindira kwemakwikwi uye njodzi dzekuvharika." Iyi dhizaini yemukati inoita seinodzivirira kuvharika kwemamorekuru, Pano'shanduro yakanyorwazve ine marongerwo akasiyana-siyana, chimiro, uye ndima uku ichichengetedza zvazvinoreva pakutanga:
Kufamba Kwezvinhu Zvishoma Nezvishoma Kwakatsauka: MaNPC Anozivisa Nzira Dzakavanzika
Panzvimbo pekufamba zvakananga kuburikidza neNPC'Muchikamu chepakati, mamorekuru anoita seanofamba nemuimwe yenzira sere dzekutakura, imwe neimwe yakavharirwa kune chimiro chakaita sespoke iri paburi.'denderedzwa rekunze. Kurongeka uku kwenzvimbo kunoratidza mashandiro ekuvaka anobatsira kudzora kuyerera kwemamorekuru.
Musser anotsanangura,"Kunyange zvazvo mbiriso yenyukireya pores ichizivikanwa kuti ine'chivhariso chepakati,'Mumagadzirirwo ayo chaiwo achiri chakavanzika. Mumasero evanhu, chimiro ichi chine'Zvakaonekwa, asi kupatsanurwa kwebasa kunogoneka—uye gomba's centre inogona kushanda senzira huru yekutumira mRNA kunze kwenyika.""
Kubatana kweZvirwere uye Matambudziko Ekurapa
Kusashanda zvakanaka muNPC—gedhi renhare rakakosha—yakabatana nezvirwere zvakakomba zvetsinga, kusanganisira ALS (Lou Gehrig).'chirwere cheAlzheimer),'s, naHuntington'chirwere cheNPC. Pamusoro pezvo, kuwedzera kwekutengeserana kweNPC kwakabatana nekufambira mberi kwegomarara. Kunyangwe kunanga nzvimbo dzakati dzemaburi kunogona kubatsira kubvisa kuvharika kana kunonoka kutakurwa kwakanyanya, Musser anonyevera kuti kukanganisa basa reNPC kune njodzi, tichifunga nezvebasa rayo guru mukurarama kwemasero.
"Tinofanira kusiyanisa pakati pezvisina kunaka zvine chekuita nekufambisa nematambudziko ane chekuita neNPC'kuunganidza kana kuputsa,""Anotaura kudaro."Kunyange zvazvo kubatana kwakawanda kwezvirwere kungangowira muchikamu chechipiri, pane zvimwe zvinosiyana—sekuchinja kwemajini e c9orf72 muALS, izvo zvinogadzira ma aggregates anovhara pores mumuviri.""
Nzira dzeMunguva Yemberi: Kugadzira Mepu yeNzira dzeKutakura Zvinhu uye Kufungidzira Mafoni Ari Mhenyu
Musser nemushandi pamwe chete naDr. Abhishek Sau, vanobva kuTexas A&M's Joint Microscopy Lab, inoronga kuongorora kana mhando dzakasiyana dzezvinhu—zvakaita sema ribosomal subunits uye mRNA—vanotevera nzira dzakasiyana kana kuti vanobatana munzira dzinoshandiswa nevanhu vakawanda. Basa ravo riri kuenderera mberi nevanoshanda navo vekuGermany (EMBL naAbberior Instruments) rinogonawo kugadzirisa MINFLUX kuti ionekwe panguva chaiyo mumasero mapenyu, zvichipa maonero asina kumboitika emafambiro ekufambisa kwenyukireya.
Ichitsigirwa nemari yeNIH, chidzidzo ichi chinochinja patsva kunzwisisa kwedu mafambiro emasero, zvichiratidza kuti maNPC anochengetedza sei kurongeka muguta guru rine vanhu vakawanda renucleus.
Nguva yekutumira: Kurume-25-2025
