Zvakangofanana nevarongi vemumaguta vanonyatsoronga kuyerera kwemotokari pakati pemaguta, maseru anotonga zvine hungwaru kufamba kwemamorekuru achiyambuka miganhu yenyukireya. Kuita sevachengeti vemagedhi, nyukireya pore complexes (NPCs) yakamisikidzwa munyukireya membrane inochengetedza kutonga kwakaringana pamusoro pekutengesa kwema molecular. Basa rinokatyamadza kubva kuTexas A&M Hutano riri kuratidza kusarudzika kwakaoma kweiyi sisitimu, inogona kupa maonero matsva ezve neurodegenerative kusagadzikana uye kukura kwegomarara.
Revolutionary Tracking yeMolecular Pathways
Chikwata chaDr. Siegfried Musser chekutsvagisa kuTexas A&M College of Medicine chakapayona ongororo yekukurumidza, kusina kudhumhana kwekufambisa kwemamorekuru kuburikidza nenyukiresi yekaviri-membrane barriers. Kudhindisa kwavo kwakakosha kweMasikirwo kunotsanangura zvakawanikwa zvakagoneka neMINFLUX tekinoroji - nzira yekufungidzira yepamberi inokwanisa kubata 3D mamorekuru ekufamba kunoitika mumamilliseconds pazvikero zvinokwana ka100,000 kupfuura hupamhi hwebvudzi remunhu. Kupesana nefungidziro dzekare pamusoro penzira dzakapatsanurwa, tsvakiridzo yavo inoratidza kuti nyukireya yekupinza uye kuendesa kunze maitiro anogovana nzira dzinopindirana mukati meNPC chimiro.
Zvinoshamisa Zvakawanikwa Dambudziko Mamodheru Aripo
Zvakaonekwa nechikwata zvakaratidza zvisingatarisirwi mafambiro emumigwagwa: mamorekuru anofamba-famba achitevedza nzira dzakamanikana, achitenderera achitenderedzana pane kutevera nzira dzakatsaurirwa. Zvinotoshamisa ndezvokuti, zvimedu izvi zvinonangana pedyo nemadziro echiteshi, zvichisiya nzvimbo yepakati isina munhu, nepo kufambira mberi kwavo kuchinodzika zvakanyanya - kanenge ka1,000 kanononoka pane kufamba kusingatadzirwe - nekuda kwekuvhiringidza mapuroteni network achigadzira nzvimbo ine syrupy.
Musser anotsanangura izvi se "inonyanya kunetsa mamiriro emumigwagwa angafungidzirwe - nzira mbiri dzinoyerera nemumigero nhete." Anobvuma kuti, “Zvatinowana zvinopa mubatanidzwa usingatarisirwi wemikana, zvichiratidza kuoma kukuru kupfuura fungidziro dzedu dzepakutanga.”
Kubudirira Pasinei Nezvipingamupinyi
Zvinoshamisa, masisitimu ekufambisa eNPC anoratidza kushanda kunoshamisa kunyangwe zvimhingamipinyi izvi. Musser anofungidzira, "Kuwanda kwechisikigo kweNPC kunogona kudzivirira kushanda kwakawandisa, nekudzikisa kupindira kwemakwikwi uye njodzi dzekuvharika." Iyi inherent dhizaini inoita seinodzivirira molecular gridlock, Pano'sa vhezheni yakanyorwa patsva ine masintakisi akasiyana, chimiro, uye kutsemuka kwendima uchichengetedza chirevo chekutanga:
Molecular Traffic Inotora Detour: NPCs Inoburitsa Yakavanzwa Nzira
Panzvimbo pekufamba wakananga muNPC'Pakati peaxis, mamorekuru anoita seanofamba nepakati peimwe yemasere akasarudzika nzira dzekufambisa, imwe neimwe yakavharirwa kune yakataura-yakafanana chimiro parutivi pore.'s mhete yekunze. Kurongeka kwenzvimbo iyi kunoratidza nzira yekuvaka iyo inobatsira kudzora kuyerera kwema molecular.
Musser anotsanangura,“Nepo mbiriso yenyukireya pores ichizivikanwa kuti ine a'central plug,'maumbirwo ayo chaiwo anoramba ari chakavanzika. Mumasero evanhu, chimiro ichi hachina't yakacherechedzwa, asi kushanda kwekubatanidza kunonzwisisika-uye pore's centre inogona kushanda senzira huru yekuburitsa kunze kwemRNA.”
Kubatana kweChirwere uye Matambudziko Okurapa
Kusashanda zvakanaka muNPC-yakakosha masero gedhi-yakasungirirwa kune zvakakomba neurological kusagadzikana, kusanganisira ALS (Lou Gehrig's chirwere), Alzheimer's, uye Huntington's chirwere. Pamusoro pezvo, kukwidziridzwa kweNPC kwekutengesa chiitiko kwakabatana nekufambira mberi kwegomarara. Kunyangwe kunanga nzvimbo dzakanangana dzepore zvichigona kubatsira kusunungura zvivharo kana kunonoka kufambisa zvakanyanya, Musser anoyambira kuti kukanganisa neNPC basa kunotakura njodzi, zvichipihwa basa rayo rakakosha mukupona kwesero.
“Tinofanira kusiyanisa pakati pezvinokanganisa zvine chekuita nekutakura uye nyaya dzakasungirirwa kuNPC's ungano kana disassembly,”anonyora.“Nepo hukama hwakawanda hwechirwere hunogona kuwira muchikamu chekupedzisira, kunze kuripo-senge c9orf72 gene mutations muALS, iyo inogadzira aggregates anovharira mumuviri pore.”
Nhungamiro Yenguva Yemberi: Kumepu Nzira Yekutakura Mitoro uye Live-Cell Imaging
Musser nemushandi Dr. Abhishek Sau, kubva kuTexas A&M's Joint Microscopy Lab, ronga kuongorora kana mhando dzakasiyana dzekutakura-senge ribosomal subunits uye mRNA-tevera nzira dzakasarudzika kana kuungana munzira dzakagovaniswa. Basa ravo rinoenderera mberi nevadyidzani veGerman (EMBL neAbberior Instruments) rinogonawo kugadzirisa MINFLUX yekufungidzira-chaiyo-nguva mumaseru mhenyu, ichipa maonero asina kumboitika ekufambisa kwenyukireya.
Ichitsigirwa nemari yeNIH, chidzidzo ichi chinogadziridza manzwisisiro edu ezvekushandisa kwenharembozha, zvichiratidza kuti maNPC anochengetedza sei kurongeka muguta rine diki diki remusiyo.
Nguva yekutumira: Mar-25-2025
