Kuvandudza Kuchengeta Kwemurwere neAI-Yakavakirwa Attenuation Kururamisa muPET Imaging

Chidzidzo chitsva chakanzi "Kushandisa Pix-2-Pix GAN yeKudzidza Kwakadzika-Yakavakirwa Muviri Wese PSMA PET / CT Attenuation Correction" ichangobva kuburitswa muVhoriyamu 15 yeOncotarget musi waChivabvu 7, 2024.

Kuratidzwa kwemwaranzi kubva kune zvakatevedzana PET / CT zvidzidzo mune oncology murwere kutevera chinhu chinonetsa. Mukuferefeta kwazvino uno, boka revaongorori vanosanganisira Kevin C. Ma, Esther Mena, Liza Lindenberg, Nathan S. Lay, Phillip Eclarinal, Deborah E. Citrin, Peter A. Pinto, Bradford J. Wood, William L. Dahut, James L. Gulley, Ravi A. Madan, Peter L. Choyke, Ismail Baris Turkbey, naStephanie A. Harmon kubva kuNational Cancer Institute paNational Institutes of Health yakaunza chigadziro cheuchenjeri hwekugadzira (AI). Ichi chishandiso chine chinangwa chekugadzira attenuation-yakagadziriswa PET (AC-PET) mifananidzo kubva isina-attenuation-yakagadziriswa PET (NAC-PET) mifananidzo, zvichigona kuderedza kudikanwa kweiyo yakaderera-dose CT scans.

"Ai-yakagadzirwa nePET mifananidzo ine mukana wekiriniki wekudzikisa kudiwa kwekugadziriswa paCT scans uchichengetedza huwandu hwemakaki uye mhando yemufananidzo kune varwere vekenza yeprostate."

Nzira: Yakadzama yekudzidza algorithm yakavakirwa pa2D Pix-2-Pix generative adversarial network (GAN) architecture yakagadziridzwa yakavakirwa papaired AC-PET uye NAC-PET mifananidzo. Iyo 18F-DCFPyL PSMA (Prostate-specific membrane antigen) PET-CT yekudzidza ye302 varwere vane kenza yeprostate yakakamurwa kuva kudzidziswa, kusimbiswa, uye kuedza mapoka (n 183, 60, uye 59, maererano). Iyo modhi yakadzidziswa uchishandisa nzira mbiri dzakamira: Yakajairwa Kutora Kukosha (SUV) yakavakirwa uye SUV-NYUL yakavakirwa. Kuongorora kwakachinjika kuita kwakaongororwa pachishandiswa normalized mean square error (NMSE), kureva absolute error (MAE), structural kufanana index (SSIM) uye peak signal-to-noise ratio (PSNR). Chiremba wemishonga yenyukireya akazoita ongororo yezinga renzvimbo yekufarira. Zviratidzo zveSUV zvakaongororwa uchishandisa intra-boka correlation coefficient (ICC), repeatability coefficient (RC), uye mutsara wakasanganiswa maitiro emhando.

Results:Mune yakazvimirira test cohort, iyo yepakati NMSE, MAE, SSIM, uye PSNR vaive 13.26%, 3.59%, 0.891, uye 26.82, zvichiteerana. Iyo ICC yeSUVmax neSUVmean yaive 0.88 uye 0.89, zvichiratidza kuwirirana kwakasimba pakati pekutanga neAI-yakagadzirwa kuwanda imaging mamaki. Zvinhu zvakadai senzvimbo yeronda, density (Hounsfield units), uye kutorwa kweronda zvakawanikwa zvichikanganisa kukanganisa kwakagadzirwa muSUV metrics (ese p <0.05).

"Iyo AC-PET inogadzirwa nePix-2-Pix GAN modhi inoratidza SUV metrics inonyatsoenderana nemifananidzo yekutanga. Mifananidzo yeAI-yakagadzirwa nePET inoratidza inovimbisa mukana wekiriniki yekudzikisa kudikanwa kweCT scans yekugadzirisa attenuation uku uchichengeta mamaki ehuwandu uye mhando yemufananidzo. "

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Sezvatinoziva tose, kusimudzirwa kweindasitiri yekufungidzira yekurapa haiparadzaniswe kubva mukugadzirwa kweakatevedzana emidziyo yekurapa - majekiseni anosiyanisa ajenti uye ayo anotsigira anobatika - ayo anoshandiswa zvakanyanya munharaunda iyi. MuChina, iyo inozivikanwa neindasitiri yayo yekugadzira, kune vagadziri vazhinji vane mukurumbira kumba nekune dzimwe nyika kugadzirwa kwemidziyo yekufungidzira yekurapa, kusanganisira.LnkMed. Kubva payakavambwa, LnkMed yanga yakatarisana nemunda weakanyanya-kudzvanya mutsauko ajenti majekiseni. Chikwata cheinjiniya cheLnkMed chinotungamirwa nePh.D. ane makore anopfuura gumi eruzivo uye akabatanidzwa zvakanyanya mukutsvaga nekusimudzira. Mukutungamirira kwake, theCT jekiseni rimwechete remusoro,CT kaviri musoro jekiseni,MRI kusiyanisa agent injector,uyeAngiography yakakwirira-kudzvanywa mumiririri jekiseniakagadzirwa aine aya maficha: iyo yakasimba uye yakabatana muviri, yakanakira uye nehungwaru mashandiro interface, mabasa akazara, kuchengetedzwa kwepamusoro, uye dhizaini yakasimba. Tinogonawo kupa majekiseni nemachubhu anofambirana neaya majekiseni ane mukurumbira eCT,MRI,DSA majekiseni Nemafungiro avo echokwadi uye simba rehunyanzvi, vashandi vese veLnkMed vanokukoka nemwoyo wose kuti uuye kuzoongorora mimwe misika pamwe chete.