Kufungidzira kwechiremba kunowanzo batsira kuongorora nekurapa kenza. Kunyanya, magnetic resonance imaging (MRI) inoshandiswa zvakanyanya nekuda kwehukuru hwayo, kunyanya ne contrast agents.
Chidzidzo chitsva chakaburitswa mujenari reAdvanced Science chinoshuma nezvechinhu chitsva chinozvipeta chenanoscale contrast chinogona kubatsira kuona bundu zvakadzama kuburikidza neMRI.
Chii chinonzi musiyanomidhiya?
Mishonga yemhando ye "contrast media" (inozivikanwawo se "contrast media") makemikari anopinzwa (kana kutorwa) munyama dzemunhu kana nhengo dzemuviri kuti awedzere kutarisisa mifananidzo. Mishonga iyi yakakora kana kuti yakaderera pane yenyama yakapoteredza, zvichiita kuti pave nekusiyana kunoshandiswa kuratidza mifananidzo nezvimwe zvishandiso. Semuenzaniso, mishonga ye "iodine", "barium sulfate", nezvimwewo zvinowanzo shandiswa pakuongorora X-ray. Inopinzwa mutsinga yeropa yemurwere kuburikidza nesirinji ine simba re "high-pressure contrast syringe".
Pachiyero chidiki, mamorekuru anoramba ari muropa kwenguva yakareba uye anogona kupinda mumabundu akaoma pasina kukonzera nzira dzekudzivirira dziviriro yemuviri. Mamorekuru akati wandei akavakirwa pamabundu madiki akaongororwa seanogona kutakura CA kuita mabundu.
Izvi zvinosiyanisa mavara (NCAs) zvinofanirwa kugoverwa zvakanaka pakati peropa nenyama yemuviri kuti zvideredze ruzha rwekumashure uye kuwana chiyero chepamusoro chechiratidzo-ku-ruzha (S/N). Kana paine huwandu hwakawanda, NCA inoramba iri muropa kwenguva yakareba, nokudaro ichiwedzera njodzi ye fibrosis yakakura nekuda kwekuburitswa kwemaion egadolinium kubva muchikamu chacho.
Zvinosuwisa kuti maNCA mazhinji ari kushandiswa parizvino ane magungano emhando dzakasiyana dzemamorekuru. Pasi pemuganho wakati, ma micelles aya kana kuti ma aggregates anowanzo patsanuka, uye mhedzisiro yechiitiko ichi haina kujeka.
Izvi zvakakurudzira kutsvagurudza muma macromolecules e nanoscale anopeta ega asina miganho yakakosha yekuparadzanisa. Izvi zvinosanganisira mafuta ari mukati uye chikamu chekunze chinonyunguduka chinodzivirirawo kufamba kwemayuniti anonyunguduka pamusoro penzvimbo yekubata. Izvi zvinogona kukanganisa mamorekuru ekuzorodza uye mamwe mabasa anogona kushandiswa kusimudzira kuendeswa kwemishonga uye hunhu hwayo muhupenyu hwemunhu.
Chinhu chinopinza hutachiona chinowanzoiswa mumuviri wemurwere kuburikidza nechinhu chinopinza hutachiona chinodzvanywa zvakanyanya.LnkMed, kambani inogadzira zvinhu ine hunyanzvi inotarisa pakutsvaga nekugadzira majekiseni ekudzivirira kupisa uye zvinodyiwa, yakatengesa zvinhu zvayoCT, MRIuyeDSAmajekiseni emagetsi ...zvinodyiwaparizvino inozivikanwa muzvipatara. Fekitori yedu ine nzira dzakasimba dzekuongorora mhando dzezvinhu, kuendesa zvinhu nekukurumidza, uye sevhisi yakazara uye inoshanda mushure mekutengesa. Vashandi vese veLnkMedTinotarisira kutora chikamu chakawanda muindasitiri ye angiography mune ramangwana, kuramba tichigadzira zvigadzirwa zvemhando yepamusoro zvevatengi, uye kupa rubatsiro kuvarwere.
Tsvagiridzo iyi inoratidza chii?
Nzira itsva inounzwa muNCA inowedzera mamiriro ekureruka kwemaprotoni kwenguva refu, zvichiita kuti ibudise mifananidzo yakajeka pahuwandu hwakaderera hwegadolinium complexes. Kuremerwa kwakaderera kunoderedza njodzi yemigumisiro yakaipa nekuti huwandu hweCA hushoma.
Nekuda kwehunhu hwekuzvipeta, SMDC inobuda ine musimboti wakakora uye nzvimbo yakazara vanhu. Izvi zvinowedzera kugadzikana sezvo kufamba kwemukati nekwechikamu kwakatenderedza SMDC-Gd interface kunogona kuganhurirwa.
Iyi NCA inogona kuungana mukati memapundu, zvichiita kuti zvikwanisike kushandisa Gd neutron capture therapy kurapa mapundu zvakananga uye zvinobudirira. Kusvika pari zvino, izvi hazvisati zvaitwa mukiriniki nekuda kwekushaikwa kwekusarudza kupa 157Gd kumapundu uye kuachengetedza ari pahuwandu hwakakodzera. Kudiwa kwekuisa jekiseni repamusoro kunobatanidzwa nemhedzisiro yakaipa uye mhedzisiro yakaipa nekuti huwandu hwakawanda hwegadolinium hwakakomberedza bundu hunodzivirira kubva pakusangana neutron.
Chikero ichi chinotsigira kuunganidzwa kwehuwandu hwemishonga hwakasarudzwa uye kugoverwa kwakakwana kwemishonga mukati memapundu. Mamorekuru madiki anogona kubuda mu capillaries, zvichikonzera kushanda kwakanyanya kwekurwisa bundu.
"Zvichienderana nekuti dhayamita yeSMDC iri pasi pe10 nm, zvatakawana zvinogona kubva mukupinda kwakadzika kweSMDC mubundu, zvichibatsira kutiza kudzivirira kwekupisa kwema neutron uye kuona kuti maerekitironi nemwaranzi yegamma zvinopararira zvakanaka mushure mekusangana nekupisa kwema neutron."
Chii chiri kukonzera izvi?
"Inogona kutsigira kugadzirwa kweSMDCs dzakagadziriswa kuti chirwere chegomarara chiongororwe zviri nani, kunyangwe kana majekiseni eMRI akawanda achidikanwa."
"Zvatakawana zvinoratidza mukana wekugadzirisa NCA kuburikidza nekugadzira mamorekuru ega uye zvinoratidza kufambira mberi kukuru mukushandiswa kweNCA mukuongorora nekurapa kenza."
Nguva yekutumira: Zvita-08-2023
