Kufungidzira kwekurapa kazhinji kunobatsira kunyatsoongorora nekurapa kukura kwegomarara. Kunyanya, magnetic resonance imaging (MRI) inoshandiswa zvakanyanya nekuda kwekugadzirisa kwayo, kunyanya nevanosiyanisa vamiririri.
Chidzidzo chitsva chakaburitswa mujenari Advanced Sayenzi inoshuma pane nyowani yekuzvipeta nanoscale musiyano mumiririri inogona kubatsira kuona mamota mune zvakadzama kuburikidza neMRI.
Chii chinonzi kusiyanamedia?
Contrast media (inozivikanwawo sekusiyana media) makemikari anobaiwa (kana kutorwa) munyama yemunhu kana nhengo kuti awedzere kutarisa kwemufananidzo. Magadzirirwo aya ane denser kana kuderera pane akatenderedza tishu, achigadzira musiyano unoshandiswa kuratidza mifananidzo nemimwe michina. Semuenzaniso, kugadzirira iodine, barium sulfate, nezvimwewo zvinowanzoshandiswa pakuongorora X-ray. Inobairwa mutsinga yeropa remurwere kuburikidza nesirinji ine high-pressure difference.
Pa nanoscale, mamorekuru anorambira muropa kwenguva yakareba uye anogona kupinda mumamota akasimba pasina kuitisa tumor-chaiyo immune immune evasion mechanism. Mamorekuru akati wandei anoenderana nanomolecules akadzidziswa seanogona kutakura CA mumamota.
Aya nanoscale akasiyana maajenti (NCAs) anofanirwa kugovaniswa zvakanaka pakati peropa nematishu ekufarira kuti aderedze ruzha rwekumashure uye kuwana yakanyanya-signal-to-noise ratio (S/N). Pakukwirira kwakanyanya, NCA inoramba iri muropa kwenguva yakareba, nekudaro ichiwedzera njodzi yefibrosis yakakura nekuda kwekuburitswa kwegadolinium ions kubva kune yakaoma.
Nehurombo, mazhinji maNCA anoshandiswa parizvino ane magungano emhando dzakasiyana dzemamorekuru. Pazasi pechimwe chikumbaridzo, aya micelles kana akaunganidzwa anowanzo patsanura, uye mhedzisiro yechiitiko ichi haina kujeka.
Iyi yakafemerwa tsvakiridzo mukuzvipeta nanoscale macromolecules asina akakomba dissociation zvikumbaridzo. Izvi zvinosanganisira mafuta core uye inonyungudika yekunze layer iyo zvakare inodzikamisa kufamba kwemayuniti anonyungudika pakatarisana nenzvimbo yekusangana. Izvi zvinogona kuzopesvedzera maparamita ekuzorodza mamorekuru uye mamwe mabasa anogona kushandiswa kuti awedzere kuendesa zvinodhaka uye hunhu hwezvivakwa mu vivo.
Contrast media inowanzobayiwa mumuviri wemurwere kuburikidza nejekiseni rinopikisa repamusoro.LnkMed, mugadziri ane hunyanzvi anotarisa pakutsvagisa nekuvandudzwa kwemajekiseni anosiyanisa ajenti uye anotsigira zvinobatika, atengesaCT, MRI,uyeDSAmajekiseni kumba nekune dzimwe nyika uye ave achizivikanwa nemusika munyika dzakawanda. Fekitari yedu inogona kupa zvese zvinotsigirazvinodyiwaparizvino yakakurumbira muzvipatara. Fekitori yedu ine yakasimba yemhando yekuongorora maitiro ekugadzirwa kwezvinhu, kukurumidza kuendesa, uye yakazara uye inoshanda mushure mekutengesa sevhisi. Vashandi vese veLnkMedtariro yekutora chikamu zvakanyanya muindasitiri yeangiography mune ramangwana, ramba uchigadzira zvigadzirwa zvemhando yepamusoro zvevatengi, uye nekupa hanya kuvarwere.
Tsvakurudzo inoratidzei?
Imwe nzira itsva inounzwa muNCA iyo inosimudzira iyo longitudinal kuzorora mamiriro eproton, ichibvumira kuti ibudise mifananidzo yakapinza pakurodha kwakadzikira kwegadolinium complexes. Kudzikira kurodha kunoderedza njodzi yemhedzisiro nekuti dhigirii reCA ishoma.
Nekuda kweiyo yekuzvipeta pfuma, iyo inoguma SMDC ine dense musimboti uye yakazara vanhu yakaoma nharaunda. Izvi zvinowedzera kuzorora sezvo mukati uye segmental kufamba kwakatenderedza SMDC-Gd interface inogona kurambidzwa.
Iyi NCA inogona kuungana mukati memamota, zvichiita kuti zvikwanise kushandisa Gd neutron capture therapy kurapa mapundu zvakanyanya uye nemazvo. Kusvika pari zvino, izvi hazvisati zvaitwa mukiriniki nekuda kwekushaikwa kwesarudzo yekuendesa 157Gd kumamota uye nekuachengeta ari munzvimbo dzakakodzera. Kudiwa kwekubaya majekiseni akakwirira kunosanganiswa nemhedzisiro yakaipa uye mhedzisiro yakaipa nekuti huwandu hukuru hwegadolinium hwakatenderedza bundu hunodzivirira kubva mukuratidzwa neutron.
Iyo nanoscale inotsigira kuunganidza kwakasarudzika kwemaitiro ekurapa uye kugovera kwakanyanya kwemishonga mukati memamota. Mamorekuru madiki anogona kubuda capillaries, zvichikonzera yakakwirira antitumor chiitiko.
“Tichifunga kuti dhayamita yeSMDC iri pasi pe10 nm, zvatinowana zvingangobva pakupinda kwakadzika kweSMDC mumamota, zvichibatsira kutiza kudzivirira kweiyo nyutroni inopisa uye kuve nechokwadi chekupararira kwakanaka kwema electrons uye gamma rays mushure mekupisa kweneutron.“
Chii chinoita?
"Inokwanisa kutsigira kuvandudzwa kweSMDCs kuti zvive nani kuongororwa kwebundu, kunyange kana majekiseni akawanda eMRI achidiwa."
"Zvatinowana zvinosimbisa mukana wekugadzirisa NCA kuburikidza nekuzvipeta-peta mamorekuru uye kuratidza kufambira mberi kukuru mukushandiswa kweNCA mukuongororwa kwegomarara uye kurapwa."
Nguva yekutumira: Zvita-08-2023
